Obock is a region in Djibouti. Its capital is Obock. Other major cities and towns include Khor Angar. The district borders Eritrea to the north, Tadjourah Region to the south-west and the Red Sea/Bab el Mandeb/Gulf of Aden to the east/south-east.

There are many salt-lakes around the districts coast. The We'ima Wenz River runs along part of the districts border with Eritrea.