Khost, sometimes spelt Khowst, is a town in Afghanistan, located at 33.3° North 69.9° East. The town of Khost is the capital of Khost Province, a mountainous region near Afghanistan's border with Pakistan.

During the Soviet occupation of Afghanistan, it was besieged for over eight years. A 'Terrorist Training Camp' was destroyed there by US cruise missiles in 1999.

Khost's airstrip, with its 9000 ft runway, served as a base for helicopter operations for both the Soviet and later US armies.